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Women often use this anabolic for the purpose of losing weight and improving relief, however, it should be borne in mind that the maximum dosage for girls is 40 mg for 4 weeks.This study was conducted as a prospective, controlled trial in which girls weighing between 13.8 and 16.8 kg were assigned to either of the two groups based on their medical histories, symptoms, lifestyle, and other medical conditions. The boys in both groups were also randomly assigned to each group in a ratio of 1:9. A total of 10 boys and 10 girls who were not in the study were excluded: those who were considered to be on antiandrogenic therapy, were on a thyroid gland supplement, did not have an above average daily weight, and were on a nonprescription diuretic. Each girl took 500 mg oral DHEA twice daily to achieve the study's requirements, with the same amount being distributed to each participant once a week.ResultsIn the placebo group, the mean BMI was 24.0 kg/m2 higher in girls than in boys (P = 0.004). The mean age of the patients was 10.2±4.4 years, and they had a median age of 15.2±2.2 years. The two groups had similar body mass index (BMI) scores (28.1±4.3 kg/m2) at the end of the trial; the mean triglycerides (TG) ratio in both the groups was 11.0% lower in girls (P = 0.0001) than in boys (P = 0.7). No differences were found in bone mineral density (BMD): the mean BMD for girls weighed 17.5±5.1 mm in female patients and 17.7±6.4 mm in male patients (P = 0.9). The mean weight loss of all patients between 21 and 35 months of age was significantly greater in females than in males (P = 0.002).DHEA levels in the blood of girls after 4 weeks of treatment were 11.9±7.8 ng/mL at week 8, 11.8±7.4 ng/mL at week 14, and 11.8±7.3 ng/mL at week 20 (P = 0.006, P = 0.002), whereas in boys the mean DHEA level was 3.6±2.3 ng/mL at week 8 and 6.8±4.0 ng/mL at week 14 (P = 0.006). The mean number of DHEA-stimulated DHEA-dependent enzymes were 7.0±3.6 inSimilar articles: